I am using Hamamatsu Photonics ORCA Flash 4.0 with the accompanied image acquisition software, HCImage. After time-lapse recordings, I prefer to save the files in the CXD format. Multiple TIFF (MPTIFF) seems to split a file larger than 4.2 GB into pieces.
Now, how can I read the CXD file in ImageJ? Luckily enough, the Bio-Formats plugin (download site) can do the job.
When you have got a lot of recordings, you may find it helpful to use a macro (CXD2TIFF_BatchProcess.txt) that automate importing and re-saving of the CXD files.